https://ehsanmisaghi.com/projects/Research/ProjectsHugoBlox Kit (https://hugoblox.com)en-usMon, 12 Jan 2026 00:00:00 -0700https://ehsanmisaghi.com/media/icon.svghttps://ehsanmisaghi.com/projects/https://ehsanmisaghi.com/projects/ai-ophthalmology/Mon, 01 Dec 2025 00:00:00 -0700https://ehsanmisaghi.com/projects/ai-ophthalmology/<h2 id="what-problem-are-we-solving">What problem are we solving?</h2> <p>The reasoning landscape of the generative AI tools within ophthalmology are understudied.</p> <h2 id="what-we-are-doing">What we are doing</h2> <p>Evaluating the reasoning capabilities of large language models in ophthalmology.</p>https://ehsanmisaghi.com/projects/clinical-ophthalmology/Fri, 01 Aug 2025 00:00:00 -0600https://ehsanmisaghi.com/projects/clinical-ophthalmology/https://ehsanmisaghi.com/projects/vessel-tortuosity/Sun, 01 Jun 2025 00:00:00 -0600https://ehsanmisaghi.com/projects/vessel-tortuosity/<h2 id="what-problem-are-we-solving">What problem are we solving?</h2> <p>Vessel tortuosity is a useful biomarker in multiple retinal and systemic conditions, but measurement is often subjective, inconsistent, or requires specialized tools that are not easily reproducible.</p> <h2 id="what-we-are-building">What we are building</h2> <p>An automated, open, and reproducible pipeline to:</p> <ul> <li>preprocess images</li> <li>segment/extract vessels (or accept vessel masks)</li> <li>compute tortuosity metrics (multiple definitions supported)</li> <li>export publication-ready summaries and QC overlays</li> </ul> <h2 id="my-role">My role</h2> <p>Primary developer and designer, algorithm selection, implementation, validation strategy, and documentation for open-source release.</p> <h2 id="current-status">Current status</h2> <p>Core pipeline stable; ongoing refinement, validation, and packaging for public release.</p> <h2 id="outputs">Outputs</h2> <ul> <li>Open-source repository (planned)</li> <li>Methods write-up and example datasets (planned)</li> </ul>https://ehsanmisaghi.com/projects/ai-medical-education/Tue, 01 Apr 2025 00:00:00 -0600https://ehsanmisaghi.com/projects/ai-medical-education/<h2 id="what-problem-are-we-solving">What problem are we solving?</h2> <p>Health professional learners are encountering AI in clinical and academic settings, but training is uneven and often not integrated into interprofessional practice contexts.</p> <h2 id="what-we-are-building">What we are building</h2> <p>A structured set of learning objectives, teaching sessions, and assessment-aligned materials integrated into an interprofessional course, paired with a scholarship-of-teaching evaluation strategy.</p> <h2 id="methods">Methods</h2> <ul> <li>Pre- and Post-session, assignment, and end-of-course survey instruments (paired)</li> <li>Descriptive and inferential analysis to characterize perceived competence, attitudes, and readiness</li> <li>Focus on practical competencies (interpretation, limitations, safety, and team-based application)</li> </ul> <h2 id="my-role">My role</h2> <p>Co-design of curriculum elements, survey/evaluation design, analysis plan, and manuscript development.</p> <h2 id="current-status">Current status</h2> <p>Data collection complete/ongoing (depending on cohort); analysis and manuscript drafting in progress.</p> <h2 id="outputs">Outputs</h2> <ul> <li>Teaching materials</li> <li>Conference abstracts &amp; talks (done)</li> <li>Scholarship-of-teaching manuscript (in progress)</li> </ul>https://ehsanmisaghi.com/projects/col4a1/Mon, 01 Jan 2024 00:00:00 -0700https://ehsanmisaghi.com/projects/col4a1/<h2 id="what-problem-are-we-solving">What problem are we solving?</h2> <p>COL4A1-associated disease spans multisystem vasculopathy with variable penetrance and under-recognized ophthalmic manifestations. Clinicians need clearer phenotype patterns, evaluation guidance, and prognostic framing.</p> <h2 id="what-we-are-doing">What we are doing</h2> <ul> <li>Synthesizing genotype–phenotype evidence with an ophthalmology-forward lens</li> <li>Identifying clinical “red flags” and workup considerations relevant to eye care</li> <li>Translational framing for counseling, surveillance, and interdisciplinary management</li> </ul> <h2 id="my-role">My role</h2> <p>Lead drafting and synthesis, organization of evidence, and integration with ongoing patient-facing work in the lab/clinic ecosystem.</p> <h2 id="current-status">Current status</h2> <p>Near-complete project with paper writing and final integration underway.</p> <h2 id="outputs">Outputs</h2> <ul> <li>Review / synthesis manuscript</li> <li>Clinical-facing tables/figures for phenotype anchoring and management considerations</li> <li>Functional study manuscript outlining a novel genetic variant in COL4A1 in a multigenerational family</li> </ul>https://ehsanmisaghi.com/projects/pikfyve/Sun, 01 Jan 2023 00:00:00 -0700https://ehsanmisaghi.com/projects/pikfyve/<h2 id="what-problem-are-we-solving">What problem are we solving?</h2> <p>Given its role in phagocytosis and its high expression in the retina, PIKFYVE is hypothesized to be important for the functions of the retinal pigment epithelium. With the increases in the applications of genetic sequencing and the identification of genetic variants, it is important to identify genes/proteins that have important roles in the retina in order to identify the causative genes for inherited retinal diseases. The field needs clearer mechanistic evidence and a defensible path from cellular phenotype to therapeutic hypotheses.</p> <h2 id="what-we-are-doing">What we are doing</h2> <ul> <li>Characterizing relevant cellular pathways and phenotypes (wet-lab + analysis)</li> <li>Connecting mechanistic findings to clinically meaningful readouts and potential interventions</li> <li>Translational framing suitable for clinician audiences and future therapeutic work</li> </ul> <h2 id="my-role">My role</h2> <p>Primary experimental design/execution, analysis, interpretation, and manuscript development with emphasis on clinical relevance.</p> <h2 id="current-status">Current status</h2> <p>Core manuscript substantially developed; targeted experiments/analyses and writing integration ongoing.</p> <h2 id="outputs">Outputs</h2> <ul> <li>Review article</li> <li>Primary research manuscript</li> <li>Conference abstracts/talks/posters</li> </ul>