https://ehsanmisaghi.com/tags/quantitative-biomarkers/Quantitative BiomarkersHugoBlox Kit (https://hugoblox.com)en-usSun, 01 Jun 2025 00:00:00 -0600https://ehsanmisaghi.com/media/icon.svghttps://ehsanmisaghi.com/tags/quantitative-biomarkers/https://ehsanmisaghi.com/projects/vessel-tortuosity/Sun, 01 Jun 2025 00:00:00 -0600https://ehsanmisaghi.com/projects/vessel-tortuosity/<h2 id="what-problem-are-we-solving">What problem are we solving?</h2> <p>Vessel tortuosity is a useful biomarker in multiple retinal and systemic conditions, but measurement is often subjective, inconsistent, or requires specialized tools that are not easily reproducible.</p> <h2 id="what-we-are-building">What we are building</h2> <p>An automated, open, and reproducible pipeline to:</p> <ul> <li>preprocess images</li> <li>segment/extract vessels (or accept vessel masks)</li> <li>compute tortuosity metrics (multiple definitions supported)</li> <li>export publication-ready summaries and QC overlays</li> </ul> <h2 id="my-role">My role</h2> <p>Primary developer and designer, algorithm selection, implementation, validation strategy, and documentation for open-source release.</p> <h2 id="current-status">Current status</h2> <p>Core pipeline stable; ongoing refinement, validation, and packaging for public release.</p> <h2 id="outputs">Outputs</h2> <ul> <li>Open-source repository (planned)</li> <li>Methods write-up and example datasets (planned)</li> </ul>